HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA PDF

The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.

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Receive exclusive offers and updates from Oxford Academic. The first human minisatellite was discovered in by A. In contrast, complex inter-allelic conversion-like events occur in the germline.

Please check for further notifications by email. Jeffreys; Sequences flanking the repeat arrays of human minlsatellites: Somatic changes are suggested to result from replication difficulties which might include replication slippageamong other phenomena.

Emery’s Elements of Medical Genetics, 12th. Minisatellites are prominent in the centromeres and telomeres of chromosomes, the latter protecting the chromosomes from damage.

While other genomes mouse, rat and pig contain minisatellite-like sequences, none was found to be hypermutable. Most users should sign in with their email address.

Citing articles via Web of Science These elements include a retroviral LTR-like sequence, from which one of the minisatellites appears to have expanded, and a recently described short interspersed repeat. Please add a reason or a talk parameter to this template to explain the issue with the article.

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Hypervariable ‘minisatellite’ regions in human DNA – Semantic Scholar

Your comment will be reviewed and published at the journal’s discretion. Abstract We present DNA sequences flanking cloned hypervariable human minisatellites. We present DNA sequences flanking cloned hypervariable human minisatellites.

Sign In Forgot password? There might be a discussion about this on the talk page. Close mobile search navigation Article navigation. In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements.

From Wikipedia, the free encyclopedia. Retrieved from ” https: This article needs attention from an expert in Regiosn. In alternative models, it is the presence of neighbouring double-strand hotspots which is the primary cause of minisatellite repeat copy number variations.

Hypervariable ‘minisatellite’ regions in human DNA

Minisatellite variant repeat mapping by PCR MVR-PCR has been extensively used to chart the interspersion patterns of variant repeats along the array, which provides details on the structure of the alleles before and after mutation. Sign in via your Institution Sign in. Views Read Edit View history.

Minisatellites consist of repetitive, generally GC -rich, [ citation needed ] motifs that range in length from 10 to over base pairs.

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Since all hypermutable minisatellites contain internal variantsthey provide extremely informative systems for analyzing the complex turnover processes that occur at this mniisatellite of tandem repeat.

Such an event would ultimately lead to the extinction of a minisatelkite minisatellite by meiotic drive. Studies have revealed distinct mutation processes operating in somatic and germline cells. You do not currently have access to this article.

Somatic instability detected in blood DNA shows simple and rare intra-allelic events two to three orders of magnitude lower than in sperm.

These variant repeats are tandemly intermingled. Finally, with the discovery of tandem iterations of simple sequence motifs, the term microsatellites was coined. Learn how and when to remove these template messages. By using this site, you agree to the Terms of Use and Privacy Policy.

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Oxford University Press is a department of the University of Oxford. Sequences flanking the repeat arrays of human minlsatellites: WikiProject Genetics may be able to help recruit an expert.

Minisatellites also constitute the chromosomal telomeres, which protect the ends of a chromosome from deterioration or from fusion with neighbouring chromosomes. You have entered an invalid code.