A gelastic seizure, also known as “gelastic epilepsy”, is a rare type of seizure that involves a sudden burst of energy, usually in the form of laughing or crying. Information regarding gelastic epilepsy, a rare form of epilepsy that involves laughter or crying and is more common in boys than girls. What is Gelastic Epilepsy? Gelastic epilepsy refers to a type of epilepsy in which the seizures are ‘gelastic’, gelastikos being the Greek word for laughter.

Author: Vudor Vicage
Country: Gambia
Language: English (Spanish)
Genre: Environment
Published (Last): 12 July 2012
Pages: 403
PDF File Size: 1.22 Mb
ePub File Size: 11.16 Mb
ISBN: 562-9-29540-989-3
Downloads: 77712
Price: Free* [*Free Regsitration Required]
Uploader: Akilabar

Diagnosis is also complicated due to the many possible causes of the seizures. Ann Indian Acad Neurol ; Currently the most effective surgical approach is the trancallosal anterior interforniceal approach, however newer approaches including epilepy endoscopic and other treatment such as radiosurgery and gamma knife have been used with success.

Gelastic Epilepsy | Epilepsy Queensland

Children might also have other types of seizures, either right after these gelastic seizures, or at other times. As noted, we did not include patients with the genetic syndrome of Pallister—Hall in our cohort. In early stages of the illness, the interictal EEG gelastiic is normal Arzimanoglou et al gflastic Mullatti et al Gelastic epilepsy and hypothalamic hamartomas: Gamma knife surgery for gelastiv related to hypothalamic hamartomas. Any third party offering or advertising on disabled-world.

Only a few reports have described control of GS with medication Mullattiin general all the studies have shown that patients with gelastic epilepsy eventually become intractable to medication Brandberg et al ; Striano et al ; Maixner All patients had been thoroughly evaluated for their IQ or developmental quotient DQas described previously Prigatano et al.


GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas.

There was a problem providing the content you requested

The majority of patients with hypothalamic hamartomas develop epilepsy that evolves into multiple seizure gelastid including focal or generalized seizures and concomitant cognitive decline and neuropsychiatric comorbidities Berkovic et al. Syndrome of hypothalamic hamartoma and gelastic seizures GS are almost always the first seizure manifestation of HH.

Retrospective analysis of surgical treatment outcomes for gelastic seizures: These structures can be detected with different imaging modalities such as computed tomography and magnetic resonance imaging. Despite the use of higher dose and several combinations of antiepileptic drugs AEDsseizure freedom or good seizure control is rarely achieved in this group of patients Harvey and Freeman Anatomical location of effective deep brain stimulation electrodes in chronic cluster headache.

This article includes a list of referencesbut its sources remain unclear because it has insufficient inline citations. Magnetoencephalography and diffusion tensor imaging in gelastic seizures secondary to a cingulate gyrus lesion.

An update in the clinical presentation, diagnosis and treatment”. The hypothalamus; morphological, functional and surgical aspects. Given these findings, we decided to carry out the rest of the analyses by merging the two gender groups together.

We believe that our study was an initial step towards identifying the neuroanatomical basis for seizure propagation in patients with laughter as the hallmark seizure semiology.

Gelastic seizure – Wikipedia

In a retrospective review of clinical and structural neuroimaging data from cases of gelastic epilepsy and hypothalamic hamartoma, we aimed to address these questions by analysing the clinical presentation and the neuroanatomical features of the hypothalamic lesions in these patients.


MR imaging epilpesy spectroscopic study of epileptogenic hypothalamic hamartomas: If the seizures are caused by a tumor, surgical removal can be attempted.

Seizure freedom Engel Class 1 was seen in 16 patients As orexin gelastoc also have ascending projections to the amygdala and basal forebrain Peyron et al.

As noted, the size of the hypothalamic hamartoma lesions was the same in patients with pure gelastic epilepsy compared with patients with gelastic epilepsy and other types of seizures. Regis et al Our analysis yielded some positive and pertinent negative findings: Compared with gealstic, adult patients have a less severe epilepsy syndrome, less severe learning and behavior difficulties, and better occupation and social status.

This view is compatible with the notion of progressive worsening of seizures with time Arita et al. Ninety-one percent of HHs in patients with isolated precocious puberty revealed a gelastif position without affecting the third ventricle. Aggression and psychiatric comorbidity in children with hypothalamic hamartomas and their unaffected siblings. Complex partial seizures are frequently seen in patients with GS associated with HHs.

Gelastic seizure

Surgical resection of HHs has been performed by approaches that reach the lesion from below or from above. Symptomatic and cryptogenic cases. The size of the hamartoma can vary from one centimeter to larger than three centimeters.

Gelastic seizures and hypothalamic hamartomas: