Request PDF on ResearchGate | Dermatitis granulomatosa intersticial con artritis | —Interstitial granulomatous dermatitis with arthritis is a systemic disease. La dermatitis granulomatosa intersticial con artritis es una enfermedad sistémica que afecta a la piel y al sistema musculosquelético. Esta nueva entidad se. Summary. An Orphanet summary for this disease is currently under development. However, other data related to the disease are accessible from the Additional.

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J Am Acad Dermatol ; Additional investigation revealed hypothyroidism and positive anti-thyroid antibodies. However, there have also been reports of occasionally pruritic or tender skin lesions, as was the case of our patient.

Autoimmune thyroiditis presenting as interstitial granulomatous dermatitis

March Pages Both forms of granulomatous dermatitis have often arisen in people with other conditions considered autoimmune in origin, implying an immune-complex mechanism may be involved in the pathogenesis. Services on Demand Article. Differential diagnosis includes other entities related to rheumatoid arthritis, such as rheumatoid nodules, rheumatoid vasculitis, palisaded neutrophilic and granulomatous dermatitis, in addition to rheumatoid neutrophilic dermatosis, which, unlike the latter, presents neutrophilic dermal infiltrate and leukocytoclasia without vasculitis under histopathology.

Besides being an uncommon clinicopathological entity, interstitial granulomatous dermatitis, also described as interstitial granulomatous dermatitis with arthritis IGDAhas shown a wide spectrum of clinical manifestations, such as linear and erythematous lesions, papules, plaques and interzticial.

The main associated disease is RA, which may be diagnosed before, concomitantly or after the onset of lesions.


Houston M, Davie B, editors. Accentuation of the process in the reticular dermis is a intersyicial feature, although abnormalities can involve the full thickness of the dermis or the superficial hypodermis. In addition, there is a variable amount of polymorphonuclear leukocytes in the infiltrate. Interstitial granulomatous dermatitis with cutaneous cords and arthritis: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial intetsticial, distribution, and reproduction in any medium, provided the original work is properly cited.

Services on Demand Journal. Rheumatoid arthritis, Dermatitis, Granuloma. The patient was treated with hydroxicloroquine with partial response. Dermis with moderate infiltrate predominantly histiocytic amid deteriorated and thickened collagen. The granulomatous reaction pattern. Clues to diagnosis in dermatopathology. Print Send to a friend Export inteesticial Mendeley Statistics.

Other search option s Alphabetical list. Check this box if you wish to receive a copy of your message. Granulomatoea is variable with remissions and exacerbations or spontaneous and complete remission of skin lesions.

Interstitial granulomatous dermatitis and paraneoplastic rheumatoid polyarthritis disclosing cancer of the lung. Interstitial granulomatous dermatitis induced by medications is known as interstitial granulomatous drug granulomagosa.

Approved by the Advisory Board and accepted for publication on Dermatologists should be alert to this diagnostic possibility, for they are already in a privileged position when monitoring these patients. The typical microscopic presentation should be that of a granulomatous dermatitis, with palisading or interstitial histiocytes, variable numbers of neutrophils and eosinophils, and scattered areas of degenerating collagen bundles.

Interstitial granulomatous dermatitis secondary to acute promyelocytic leukemia.

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The features of interstitial granulomatous granulomatoea are variable. Autoimmune thyroiditis has already been mentioned once in association with IGD. Romiti R, Sakai N. Detail of interstitial granulomatous infiltrate amid thickened collagen. This item has received. Granuloma annulare also presents with papules and plaques but these are typically on the back of the hands or feet, whereas the trunk is a more common site for interstitial granulomatous dermatitis.


A disorder associated with autoantibodies. We also make a differential diagnosis with interstitial granuloma annulare and granulomaosa the latest articles published in literature. A review of the cutaneous manifestations.

Interstitial granulomatous dermatitis: rare cutaneous manifestation of rheumatoid arthritis

Although the original manifestation had been described as subcutaneous linear nodules, also known as rope sign 1later reports showed a clinical spectrum quite heterogeneous which vary from hyperpigmented, erythematous papules, subcutaneous plaques, annular lesions to firm red-purplish nodules as observed in our patient. However, several different types of rash have been described with the same histological appearance.

Interstitial granulomatous dermatitis was initially described by Ackerman et al in One case associated with SLE responded well to systemic steroids after 15 days. RA, diagnosed 10 years ago with symmetrical deforming polyarthritis of the small-joints of hands and being monitored by the Rheumatology Service of HSPE-SP; deramtitis arterial hypertension and obesity. National Center for Biotechnology InformationU.