Correspondence from The New England Journal of Medicine — Cellulitis. To the Editor: In their article on the Prophylactic Antibiotics for the Treatment of Cellulitis at Home I (PATCH I) trial, Thomas et al. (May 2 issue)1 report that the. In a recent retrospective study of patients who were hospitalized with presumed cellulitis, dermatologists concluded that roughly 30% of.

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Penicillin to prevent recurrent leg cellulitis.

Is it chronic changes of venous stasis and chronic ulceration? Skip to main content.

Many antibiotics increase the risk of bleeding with anticoagulants. Prophalactic antibiotics for the prevention of cellulitis erysipelas of the leg: We conducted a double-blind, randomized, controlled trial involving patients with two or more episodes of cellulitis of the leg who were recruited in 28 hospitals in the United Kingdom and Ireland. Refer for specialist opinion if severe infection Is it cellulitis?


Leg Ulcers and recurrent cellulitis

Because the risk of recurrence was not constant over the 3-year period, the primary hypothesis was tested during prophylaxis only. In patients with recurrent cellulitis of the leg, penicillin was effective in preventing subsequent attacks during prophylaxis, but the protective effect diminished progressively once drug therapy was stopped.

Doses are oral and for adults unless otherwise stated. A total of patients were recruited. Penecillin to prevent leg cellulitis NEJM ; The median time to a first recurrence of cellulitis was days in the penicillin group and days in the placebo group.

Leg Ulcers and recurrent cellulitis –

We compared prophylactic low-dose penicillin with placebo for the prevention of recurrent cellulitis. Antibiotics do not improve healing unless active infection. Leg Ulcers and recurrent cellulitis. Are they suitable for compression? Comments from Expert Advisory Committee Antibiotics do not improve healing unless active infection. The primary outcome was the time to a first recurrence.

Please refer to our Drug Interactions Table for further information. Bilateral cellulitis is uncommon. Review antibiotics after culture results.


Penicillin to prevent recurrent leg cellulitis.

Cellulitis of the leg is a common bacterial infection of the skin and underlying tissue. Amiodarone and drugs which prolong the QT interval can interact with many antibiotics.

Treat tinea pedis or candida infection with topical terbenifine or miconazole respectively. Participants were followed for up to 3 years. Randomization was performed according to a computer-generated code, and study medications penicillin [ mg twice a day] or placebo for 12 months were dispensed by a central pharmacy.

cllulitis Baseline characteristics were similar in the two groups. Comment in N Engl J Med. N Engl J Med. Overall, participants in the penicillin group had fewer repeat episodes than those in the placebo group vs.

Colonisation is likely in leg ulcers. Statins can interact with some antibiotics and increase the risk of rhabdomyolysis.